Aug 15, 2014
Is potentially not saving one patient a worthwhile sacrifice if that loss helps pave the way for future saves? Is this ethical? These are two questions that Warwick University in England is having to tackle as they prepare to involuntarily enlist patients in a study to find out how effective epinephrine is in helping achieve ROSC and favorable long term outcomes. While long overdue, a study like this toes a fine line between what is ethical and the opportunity to answer a long debated question of whether or not epinephrine actually makes a difference in cardiac arrest. The results of this study could pave the way for some major changes in cardiac arrest management. The study will evaluate 8,000 out of hospital cardiac arrests with patient either receiving epinephrine or a placebo with outcomes evaluated after the arrest. The problem with studies on cardiac arrest is there will be a patient population that you just don’t get back and others where we achieve ROSC with very few interventions at all. In other words, sometimes even if you throw everything including the kitchen sink at a patient who arrests right in front of you, you still might not get them back. Still though, if things go as they hope they will, England could see an improvement on their dismal 6% out of hospital ROSC rate. I am sure that despite overwhelming support from the medical community in England, some will try and poke holes in the ethical aspect of this study. When any medic hears the words “CPR in progress” we immediately shift gears, and many of us will turn up the intensity and focus a notch or two. We know what the task at hand is. This is our bread and butter, it is what we are trained for. It is a true medical emergency. The prospect of possibly not doing everything we can for a patient in cardiac arrest is one that some will struggle with. When looking at the bigger picture though, with the right evidence the results of this study could be earth shaking. Personally though, I am happy that someone has finally built up enough guts to tackle this one....
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